منابع مشابه
SIRT-ain relief from age-inducing stress
Aging is one of the most fundamental biological processes. It results in a decline in physiological function and an increased risk for pernicious diseases such as cancer. Oxidative stress has been proposed as a major cause of aging, but experimental tests of this hypothesis have been discouraging. Calorie restriction (CR) prevents age-related decline, but there are still gaps in our knowledge o...
متن کاملAIN: A Blueprint for an All-IP Data Center Network
With both Ethernet and IP powering Data Center Networks (DCNs), one should wonder if their coexistence is necessary or an unquestioned legacy. Especially in cloud DCNs, the role of layer-2 is diminishing rapidly as the vast majority of applications only require layer-3 connectivity. At the same time, cloud workloads are demanding that DCN architectures better support network scalability, multit...
متن کاملPollen spares all but self
Models based on the crystal structure of interleukin-1 vary significantly. D eP ri st o/ El se vi er UK) warns that, for any given structure in the Protein Data Bank (PDB), there will be many other overlooked structures that are equally consistent with the data. Crystallized proteins retain the ability to move around, thus making interpretations of diffraction data an imprecise process. Crystal...
متن کاملAcute coronary disease Athero-Inflammation: Therapeutic approach
Antithrombotic therapy is the cornerstone of the treatment of acute coronary syndromes, but there is now evidence which indicates that by blocking inflammation, thrombosis and thus, acute coronary events, could be lowered. The concept of athero-inflammation emerges as the meeting point of different morbidities; dyslipemia, diabetes, hypertension, obesity, immunity, infection, hyperhomocyteinemi...
متن کاملPPARγ: no SirT, no service.
A novel mechanism has been defined for controlling per-oxisome proliferator-activated receptors γ (PPARγ) activity in response to thiazolidinedione (TZD) ligands, in which deacetylation of PPARγ by SirT1 remodels the transcriptional complex. This change favors expression of genes associated with increased energy use and insulin sensitization in white adipose tissue (WAT), and is required for a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2012
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2641